St. Louis is an independent city on the eastern border of Missouri, United States, and is the second-largest city in the state. With a population of 318,069 in July 2011, it was the 58th-largest U.S. city at the 2010 U.S. Census. The Metropolitan Statistical Area (MSA) population of 2,812,896 is the 18th-largest in the country. The Greater St. Louis combined statistical area's (CSA) population of 2,882,932 is the 15th-largest CSA in the country, the fourth-largest in the Midwest. The Greater St. Louis area is the largest metropolitan area in Missouri.